Herbs, rarely subshrubs, annual or perennial; trichomes simple (branched in Tidestromia). Stems without nodal spines (Amaranthus spinosus sometimes with paired nodal spines). Leaves alternate or opposite, exstipulate, usually petiolate; blade margins entire (entire or serrulate in Iresine; entire, crispate, or erose in Amaranthus). Inflorescences cymules arranged in spikes, panicles, thyrses, heads, glomerules, clusters, or racemes; each flower subtended by 1 bract and 2 bracteoles (latter sometimes 1 or absent in Amaranthus). Flowers bisexual or unisexual (plants then monoecious or dioecious), hypogynous, generally small or minute; tepals mostly (1-)4-5 or absent, distinct or connate into cups or tubes, scarious, chartaceous, membranaceous, or indurate; stamens 2-5, filaments basally connate into cups or tubes, rarely distinct, alternating with pseudostaminodes (appendages on staminal tubes) or not, anthers 2-locular with 1 line of dehiscence or 4-locular with 2 lines of dehiscence; ovary superior, 1-locular; ovules 1 or, rarely, 2-many; style 1 or absent; stigmas 1-3(-5). Fruits utricles, dry, dehiscent or not. Seeds black, reddish brown, or brown, lenticular, subglobose or globose (rarely cylindric), usually small; embryo peripheral, surrounding mealy perisperm.

Centers of diversity for Amaranthaceae are southwestern North America, Central America, South America, and Africa south of the Sahara Desert. Generic limits are not well defined in some groups; fewer than 60 or more than 70 genera could be recognized.